First Detected Human Case in Algeria of mcr-1 Plasmid-Mediated Colistin Resistance in a 2011 Escherichia coli Isolate.
نویسندگان
چکیده
Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Marseille, France; Laboratoire Antibiotiques, Antifongiques, Physico-chimie, Synthèse et Activité Biologiques (LAPSAB), Faculté des Sciences de la Nature, de la Vie, de la Terre, et de l’Univers, Université Abou Bekr Belkaid—Tlemcen, Tlemcen, Algeria; Département de Biologie, Faculté des Sciences de la Nature, de la Vie, de la Terre, et de l’Univers, Université Abou Bekr Belkaid—Tlemcen, Tlemcen, Algeria
منابع مشابه
Colistin Resistance in Escherichia coli Isolates From Patients With Bloodstream Infection in Korea
Dear Editor, Colistin is the last line of defense for carbapenem-resistant Enterobacteriaceae (CRE) or Acinetobacter baumannii infection [1]. Recently, a plasmid-mediated colistin resistance mechanism (mcr-1 gene) was identified in human, animal, and environmental isolates in China, and the worldwide spread of the mcr-1 gene has continuously been reported [2]. This colistin resistance mechanism...
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The plasmid-mediated colistin resistance gene, mcr-1, was detected in an Escherichia coli isolate from a Danish patient with bloodstream infection and in five E. coli isolates from imported chicken meat. One isolate from chicken meat belonged to the epidemic spreading sequence type ST131. In addition to IncI2, an incX4 replicon was found to be linked to mcr-1. This report follows a recent detec...
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Enterobacteriaceae carrying plasmid-mediated colistin resistance have been found around the world. We report here the high-quality whole-genome sequence of an Escherichia coli O157:H48 isolate (2016C-3936C1) from Connecticut that carried the mcr-1 resistance gene on an IncX4-type plasmid.
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The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the Gen...
متن کاملInvestigation of Escherichia coli Harboring the mcr-1 Resistance Gene - Connecticut, 2016.
The mcr-1 gene confers resistance to the polymyxins, including the antibiotic colistin, a medication of last resort for multidrug-resistant infections. The mcr-1 gene was first reported in 2015 in food, animal, and patient isolates from China (1) and is notable for being the first plasmid-mediated colistin resistance mechanism to be identified. Plasmids can be transferred between bacteria, pote...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 60 11 شماره
صفحات -
تاریخ انتشار 2016